Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
Abstract Objective To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regards to their relevance to epilepsy and other selected neuropsychiatric disorders. Methods We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiology, mechanisms of action, pharmacology and data from studies with animal models and human subjects. Results...
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
OBJECTIVES: This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis. METHODS: Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources. RESULTS: Migraine has...
Study: Ultra-Low Doses Of THC May Help Protect Against Neurodegenerative Disease
There is a great deal of evidence suggesting that cannabis could be beneficial for the prevention and treatment of neurodegenerative diseases like Alzheimer’s disease and Parkinson’s. In fact, a Brazilian study published last year suggests that cannabidiol (CBD) could help ward off neuronal cell death in the face of neurodegradation.In order to provide more insight on the topic of medical marijuana and neurodegenerative disease, a...
Cannabis : préventif des lésions cérébrales ?
La marijuana est une drogue récréative bien connue, mais pas que…; d’ailleurs des recherches scientifiques approfondies ont été menées sur les propriétés thérapeutiques de la marijuana dans la dernière décennie. De même, des constations de certains malades et médecins les suivant, sur l’amélioration des symptômes liés à certaines maladies, tendent à démontrer également, que le cannabis médical serait d’une aide précieuse pour les...
The Endocannabinoid System, Cannabinoids, and Pain
Rambam Maimonides Med J. Oct 2013; 4(4): e0022. Published online Oct 29, 2013. doi: 10.5041/RMMJ.10129 PMCID: PMC3820295 The Endocannabinoid System, Cannabinoids, and Pain Abstract The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors...
Study: Cannabidiol (CBD) May Help Fight Cognitive Impairments From Alzheimer’s
There is a great deal of evidence suggesting that cannabis is beneficial for the prevention and treatment of neurodegenerative diseases. It shows particular promise in the case ofAlzheimer’s disease, and Clint Werner covers the topic in detail in his book Marijuana Gateway to Health.With that said, a group of Australian researchers, led by Dr. Tim Karl, published a study in this month’s edition of Psychopharmacology that offers...